During the Drug Trafficking and Snatch missions, take advantage of the fact that you can switch cars - if you jump into another car, the dealer/hos will hop into whatever car you're in.The storyline and sense of progression is way better that way. If you possibly can do the gangs in this order: Sons of Samedi -> Ronin -> Brotherhood.You'll be exploring Stilwater a lot and having all of them handy is nice for when you catch a glimpse of a target.
It's basically the essential mod, fixes lots of bugs and performance issues and improves the game massively overall.